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This paper assessed differences in mental health outcomes based on exposure to discrimination among transgender female youth in the San Francisco Bay Area aged 16–24 years. Logistic regression models were used to estimate odds ratios for the mental health outcomes, comparing levels of discrimination and levels of resiliency promoting protective factors among sexually active youth in the sample. It was found that Transgender and racial discrimination increased the odds of adverse mental health outcomes like PTSD and stress related to suicidal thoughts. Parental closeness was related to significantly lower odds of all four mental health outcomes measured.