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The paper explores differences in self-rated health and subjective well-being between individuals living in same-sex and opposite-sex couples using the 2010 European Social Survey (n = 50,781). 315 individuals living with a same-sex partner were matched and compared with an equal number of individuals living in opposite-sex couples. They also examined the effects of discrimination and country-level variations in LGB acceptance on health and well-being and the potential mediating role of social capital in these associations. Structural Equation Modeling analyses were used to estimate path coefficients, mediations and interactions.