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This systematic review explores the interaction between social inequality and the processes of exclusion and marginalisation related to HIV/AIDS stigma and discrimination in recent studies. The selected studies reported that the axes of inequality examined in the literature were linked to specific cultural and socio-economic dimensions and analysed as factors that behave synergistically to increase social groups’ vulnerability to HIV. While half of the 42 articles viewed expression of stigma/discrimination to be the result of power dynamics that reinforce the processes of social exclusion. The other half of the articles tended to describe stigma as intrinsic to social interaction.